SubtiBank SubtiBank
pksN [2018-02-13T14:27:54.000Z]
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pksN [2018-02-13T14:27:54.000Z]

polyketide synthase of type I
Locus
BSU17210
Isoelectric point
5.47
Molecular weight
609.00 kDa
Protein length
5488 aa Sequence Blast
Gene length
16464 bp Sequence Blast
Function
polyketide synthesis
Product
polyketide synthase of type I
Essential
no
Synonyms
pksP
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Metabolism → Additional metabolic pathways → Miscellaneous metabolic pathways → Biosynthesis of antibacterial compounds
  • Lifestyles → Coping with stress → Biosynthesis of antibacterial compounds

    • Gene

    Coordinates
    1,834,409 → 1,850,875

    The protein

    Paralogous protein(s)

  • shares highly conserved domains of more than 1,000 amino acids with: DhbF, PksJ, PksN, PpsA, PpsB, PpsC, PpsD, PpsE, SrfAA, SrfAB, SrfAC

    • Expression and Regulation

    Operons

    Genes
    pksC-pksD-pksE-acpK-pksF-pksG-pksH-pksI-pksJ-pksL-pksM-pksN-pksR
    Description
    PubMed

    Regulatory mechanism

  • AbrB: repression, PubMed, in AbrB regulon
  • CodY: activation, PubMed, in CodY regulon

    • Regulation

  • expressed during the transition from growth to stationary phase (AbrB, CodY) PubMed

    • Additional information

  • this is a very large operon comprising about 75 kb
    • view in new tab

    Genes
    pksB-pksC-pksD-pksE-acpK-pksF-pksG-pksH-pksI-pksJ-pksL-pksM-pksN-pksR
    Description
    PubMed
    view in new tab

    Biological materials

    Mutant

  • BKE17210 (ΔpksN::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATGCCTTTAAGATGTTCTT, downstream forward: _UP4_CTGTTATAGGAGGGGAAACG
  • BKK17210 (ΔpksN::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATGCCTTTAAGATGTTCTT, downstream forward: _UP4_CTGTTATAGGAGGGGAAACG

    • References

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